Overview
Airway management failure accounts for 8-15% of potentially preventable trauma deaths. In the rural and remote Australian context, the stakes are amplified: specialist backup is often hours away, retrieval may be delayed, and the rural generalist must execute a full spectrum of interventions, from basic manoeuvres to surgical cricothyrotomy, with limited personnel and equipment.
Core principles:
- Oxygenation is always the primary goal.
- Not every patient requires intubation; basic manoeuvres or supraglottic devices may suffice until a more controlled environment is available.
- Every emergency airway must be assumed potentially difficult; every management plan must include a plan for failure.
- A definitive airway = a cuffed device placed in the trachea below the vocal cords (cuffed ETT or surgical airway).
- Intubation (outside cardiac arrest) is performed as modified RSI, the terms RSI and modified RSI are used interchangeably.
Indications for Airway Intervention
| Clinical Scenario | Urgency |
|---|---|
| Inability to oxygenate by any other means | Immediate |
| Airway bleeding, regurgitation, or emesis compromising patency | Immediate |
| Unconsciousness / GCS ≤ 8 | Urgent |
| Respiratory failure or impending arrest | Urgent |
| Burns with signs of impending obstruction (stridor, facial oedema, decreased SpO₂, suprasternal retraction, full-thickness facial burns, decreased consciousness) | Urgent-Immediate |
| Penetrating or blunt neck/airway trauma | Urgent |
| Definitive airway required for safe transfer | Planned |
Timing of RSI, Factors to Consider
| Factors Favouring Immediate RSI | Factors Favouring Deferral |
|---|---|
| Cannot oxygenate via mask or supraglottic airway | Adequate resuscitation not yet achieved |
| Inability to maintain airway patency (bleeding, emesis) | Well-functioning supraglottic device or patient self-maintaining airway |
| Definitive airway needed for safe transfer | Haemodynamic instability not yet treated |
| Anticipated deterioration | Inadequate intubation experience or insufficient staff |
| Rapid availability of airway specialist | |
| Anticipated difficult airway with expert help imminent |
A functioning prehospital supraglottic airway providing adequate oxygenation may be continued, with replacement deferred until optimal personnel and equipment are available.
Assessment
Anatomical Predictors of Difficult Airway
| Risk Factor | Clinical Implication |
|---|---|
| Short thyromental distance (< 6 cm) | Anterior larynx, poor laryngoscopic view |
| Restricted mouth opening / jaw protrusion | Difficult blade insertion |
| Retrognathia | Difficult laryngoscopy |
| Obesity / short neck | Reduced FRC, rapid desaturation |
| Beard | Poor BVM seal during mask ventilation |
| Cervical spine immobilisation (MILS/collar) | Reduced neck mobility |
| Previous neck surgery or radiotherapy | Anatomical distortion |
| Pregnancy | Reduced FRC, aspiration risk, airway oedema |
| Obstructive sleep apnoea | Soft tissue obstruction |
| Airway burns / direct airway trauma | Dynamic obstruction, may deteriorate rapidly |
| Large or abnormal neck anatomy | Difficult surgical airway landmark identification |
A reassuring assessment does not exclude difficult airway. Always prepare for failure.
Physiological Predictors of Peri-intubation Risk
- Hypotension: Sedative agents and positive-pressure ventilation reduce preload and can precipitate cardiovascular collapse, fluid resuscitate before RSI; prepare vasopressors.
- Hypoxia: Reduced reserve in obese, pregnant, paediatric, and patients with pre-existing lung disease, maximise preoxygenation.
- Raised ICP: In TBI, laryngoscopy without adequate sedation raises BP and ICP; apnoea causes hypercapnia and further ICP elevation.
- Hyperkalaemia risk with suxamethonium: Contraindicated > 24 hours after extensive burns, prolonged immobilisation, or spinal cord injury.
Investigations
| Investigation | Rural Availability | Clinical Use |
|---|---|---|
| Pulse oximetry (SpO₂) | Universal | Continuous; guide preoxygenation and post-intubation monitoring |
| Waveform capnography (EtCO₂) | Most rural EDs | Mandatory ETT confirmation (≥ 7 sustained breaths); ongoing ventilation monitoring |
| Colorimetric CO₂ detector | All rural EDs (minimum) | Acceptable backup if waveform capnography unavailable |
| ECG | Universal | Continuous monitoring during RSI |
| NIBP | Universal | 1-minute cycle during peri-intubation period |
| POC blood gas (e.g. iSTAT) | Many rural EDs | Pre/post-intubation ventilation and metabolic status |
| Chest X-ray | Most rural EDs | Post-intubation ETT position, pneumothorax |
| POCUS (linear probe) | Selected rural EDs | Localise cricothyroid membrane in obese/oedematous patients; lung sliding to confirm bilateral ventilation |
| Telemedicine / telehealth | Statewide | Real-time specialist guidance for difficult airway planning |
Capnography is the gold standard for ETT confirmation, clinical signs alone (chest rise, air entry, SpO₂) are insufficient and unreliable.
Management
Airway Intervention Spectrum
Escalate stepwise unless immediate advanced airway is mandated:
- Basic manoeuvres, chin lift, jaw thrust; allow spontaneous positioning if patient is oxygenating (especially trauma/airway injury patients)
- Adjuncts, oropharyngeal airway (OPA), nasopharyngeal airway (NPA, avoid if base-of-skull fracture suspected), wide-bore suction
- Supraglottic airway, LMA / i-gel as bridge, temporising, or rescue device
- Tracheal intubation via modified RSI
- Surgical airway, when above measures fail or are contraindicated
Modified RSI
Pre-RSI Preparation Checklist
Use a structured checklist before every RSI. Key elements:
| Domain | Checklist Items |
|---|---|
| Physiological | IV/IO access ×2; resuscitation sufficient; haemodynamics assessed; vasopressor drawn |
| Preoxygenation | High-flow O₂ initiated; apnoeic oxygenation planned |
| Positioning | Head-up/ramped; MILS if C-spine concern |
| Monitoring | SpO₂, EtCO₂, ECG, NIBP on 1-minute cycle |
| Equipment | Suction ×2 checked; laryngoscopes ×2 checked; ETT ×2 cuffs checked; bougie; stylet; syringe; BVM with PEEP valve; OPA; NPA; LMA; surgical airway kit; O₂ supply confirmed |
| Drugs | Induction agent drawn; NMBD drawn; vasopressor(s) drawn; post-intubation sedation ready |
| Team | Roles allocated; intubation plan communicated; failed intubation plan stated; surgical airway plan stated; deterioration plan stated |
Preoxygenation and Apnoeic Oxygenation
- High-flow O₂ via non-rebreather mask (15 L/min) for ≥ 3 minutes; or 8 vital capacity breaths where time is critical.
- In the obtunded patient, assisted BVM ventilation may be required.
- Apnoeic oxygenation: nasal cannulae at 15 L/min maintained throughout laryngoscopy, significantly extends safe apnoea time, particularly important in obese patients, children, and pregnant patients who desaturate rapidly.
RSI Medications
| Drug | Class | Dose | Key Considerations |
|---|---|---|---|
| Ketamine | Dissociative anaesthetic | 0.5-2 mg/kg IV (RSI); 0.5 mg/kg sedation | Drug of choice in haemodynamically unstable patients; bronchodilator; may raise BP/ICP, use with caution in isolated TBI, though current evidence does not absolutely contraindicate it |
| Etomidate | Hypnotic | 0.2-0.3 mg/kg IV | Haemodynamically stable; single dose acceptable; adrenal suppression concern with infusion |
| Propofol | Hypnotic | Experienced clinician only | Avoid or drastically reduce (up to 90% dose reduction) in shocked patients, profound hypotension risk |
| Midazolam | Benzodiazepine | Reduce 20-40% in elderly/shocked | Hypotension risk; slower onset |
| Fentanyl | Opioid | 0.5-1 mcg/kg | Adjunct sedation/analgesia |
| Suxamethonium | Depolarising NMBD | 1 mg/kg IV | Onset 45-60 sec; offset 3-5 min; contraindicated > 24 h post-extensive burns, prolonged immobilisation, spinal cord injury (fatal hyperkalaemia risk); causes fasciculations |
| Rocuronium | Non-depolarising NMBD | 1.2 mg/kg IV for RSI conditions | Equivalent intubating conditions to suxamethonium at ≥ 1.2 mg/kg; reversible with sugammadex |
$$\text{Rocuronium RSI dose} = 1.2 \; \text{mg/kg}$$
Vasopressors (prepared before induction, not a substitute for volume):
| Agent | Dose |
|---|---|
| Metaraminol | 0.5-1 mg IV boluses (or 10 mcg/kg) |
| Phenylephrine | 50 mcg IV boluses (or 1 mcg/kg) |
| Ephedrine | 6 mg IV boluses (or 0.5 mg/kg) |
| Epinephrine (adrenaline) | 10-50 mcg IV boluses; 0.05-2 mcg/kg/min infusion |
| Norepinephrine (noradrenaline) | 0.1-1 mcg/kg/min infusion (dilute, reliable access) |
All sedative agents can cause or worsen haemodynamic derangement, doses are reduced compared to elective intubation. Fluid resuscitation precedes RSI in haemodynamically unstable patients; vasopressors treat vasodilation from sedatives, not shock itself.
Sugammadex
If rocuronium is used and surgical airway is not feasible, sugammadex 16 mg/kg IV can reverse profound neuromuscular blockade. However, this is not a routine rescue strategy, waking a trauma patient is rarely a viable option. Stock sugammadex in rural EDs where rocuronium is used.
Laryngoscopy
- Approximately 60 seconds after NMBD administration, attempt laryngoscopy.
- Video laryngoscopy (VL) is preferred for trauma intubations, superior first-pass success rates. Standard-geometry VL blades (similar to Macintosh) are appropriate for less experienced operators. Extended-angle blades require additional training.
- Direct laryngoscopy (DL) with Macintosh blade: standard fallback for all rural generalists.
- Bougie (gum-elastic bougie / Eschmann introducer): use early when view is suboptimal; angled tip facilitates anterior passage; railroad ETT over bougie.
- BURP manoeuvre: backward, upward, rightward pressure on larynx by assistant improves laryngoscopic view; also termed external laryngeal manipulation.
- C-spine: MILS by dedicated assistant; remove anterior portion of cervical collar while maintaining MILS.
- If first attempt fails: change something (position, equipment, operator, removal of obstructing material), identical repeated attempts are unlikely to succeed.
Attempt Limits and Escalation
- Maximum 3 laryngoscopy attempts per operator; one further attempt by a more experienced operator is permitted.
- BVM or LMA ventilation is performed between every attempt, do not allow progressive desaturation.
- Every attempt risks progressive oedema and airway injury, fewer attempts are often better.
Confirmation of ETT Placement
- Mandatory primary confirmation: sustained EtCO₂ waveform present for ≥ 7 breaths.
- Secondary: bilateral air entry, symmetric chest rise, SpO₂ trend improvement.
- Visualisation of tube passing through cords is unreliable alone.
- Oesophageal intubation = absent sustained EtCO₂ → remove tube immediately → ventilate via BVM/LMA → do not reattempt until SpO₂ improved.
- Document ETT depth at teeth/gums; secure tube; reassess after every patient movement.
Difficult Airway Algorithm
PREOXYGENATION + APNOEIC OXYGENATION
↓
TRACHEAL INTUBATION ATTEMPTS (max 3; change technique/operator each attempt)
↓ FAIL → Declare "Failed Intubation"
RESCUE AIRWAY: LMA or BVM (max 3 attempts at each; switch if unsuccessful)
↓ FAIL → Declare "Cannot Intubate, Cannot Oxygenate (CICO)"
SURGICAL AIRWAY: Scalpel-Bougie-Tube
Surgical Airway, Emergency Cricothyrotomy
Indication: CICO situation, failure of tracheal intubation AND supraglottic/BVM rescue. Once initiated, persist and secure the airway regardless of challenges encountered.
Preferred technique: Scalpel-Bougie-Tube
| Step | Action |
|---|---|
| 1. Identify | Locate cricothyroid membrane (CTM): midline, between thyroid and cricoid cartilages. Use POCUS (linear probe) if landmarks are impalpable (obesity, oedema, trauma). |
| 2. Stabilise | Non-dominant hand: laryngeal handshake to stabilise larynx. |
| 3. Incise | Horizontal stab incision through skin and CTM with No. 10 or 20 scalpel blade (~1.5-2 cm). |
| 4. Open | Extend and hold incision open with tracheal hook or index finger. |
| 5. Insert bougie | Pass bougie caudally into trachea. |
| 6. Railroad | Pass cuffed 6.0 mm ETT (or purpose-made cricothyrotomy tube) over bougie into trachea. |
| 7. Confirm | Inflate cuff, ventilate, confirm with sustained EtCO₂. |
| 8. Secure | Secure device immediately; document depth. |
$$\text{Once committed to surgical airway, persist. Do not abandon the procedure.}$$
Rural requirement: Every rural ED must have a pre-packed surgical airway kit (scalpel, tracheal hook, bougie, 6.0 mm cuffed ETT, syringe, tape/securing device). Rehearse this procedure in simulation at least annually.
Post-Intubation Management
Use a structured post-intubation checklist:
| Domain | Actions |
|---|---|
| Airway | Confirm sustained EtCO₂; bilateral air entry; document depth at teeth; secure tube; check cuff pressure; reassess after every patient movement |
| Breathing | Safe ventilation initiated; ventilator alarms set; CXR arranged; ABG checked; DOPE mnemonic if deterioration occurs |
| Circulation | Resuscitation continued; vasopressors and fluids available; haemodynamics reassessed |
| Disability | Sedation and analgesia established; head-up position if able; TBI targets maintained; C-spine collar reapplied if applicable |
| Environment | Backup BVM available; O₂ supply adequate; gastric tube inserted |
DOPE mnemonic, causes of post-intubation deterioration:
- D, Displacement (ETT right mainstem or dislodgement)
- O, Obstruction (mucous plug, kink)
- P, Pneumothorax (tension, from positive-pressure ventilation)
- E, Equipment failure (disconnect from ventilator → manual ventilation)
Special Populations
Traumatic Brain Injury (TBI)
- Prevent secondary injury: avoid hypotension, hypoxia, and hypercapnia.
- Laryngoscopy without adequate sedation raises BP and ICP, ensure adequate induction agent dose.
- Apnoea causes hypercapnia and raises ICP, minimise apnoea time.
- Post-intubation: target normocapnia (EtCO₂ 35-40 mmHg); MAP > 80 mmHg; SpO₂ ≥ 95%.
- Ketamine: historical concerns about ICP elevation are not supported by current evidence; remains a reasonable choice especially when haemodynamic instability coexists.
Paediatric Patients
- All airway structures proportionally smaller, use age-appropriate equipment.
- Larger occiput: place shoulder roll (not pillow) to achieve neutral alignment.
- Miller (straight) blade preferred in infants.
- Cuffed ETTs are appropriate for emergency trauma intubations in all age groups, including small children.
- Rapid desaturation due to low FRC, preoxygenation and apnoeic oxygenation are critical.
$$\text{ETT internal diameter (mm)} = \frac{\text{age (years)}}{4} + 4$$
$$\text{ETT insertion depth at lips (cm)} = \frac{\text{age (years)}}{2} + 12$$
Obstetric Patients
- Reduced FRC (elevated diaphragm), increased aspiration risk (reflux, reduced lower oesophageal sphincter tone), airway oedema.
- Physiological challenges similar to obese patients.
- Left lateral tilt after 20 weeks to relieve aortocaval compression.
- Early RFDS/retrieval involvement.
Elderly Patients
- Reduced protective airway reflexes, high aspiration risk; act decisively.
- Arthritis restricts mouth opening and neck mobility, may worsen with cervical collar.
- Dentures: remove for intubation; leave in place during BVM ventilation to maintain mask seal; if removed, pack gauze between gums and cheek.
- Absence of teeth simplifies intubation but complicates BVM ventilation.
- Reduce RSI sedative doses by 20-40% (barbiturates, benzodiazepines, other sedatives) to reduce cardiovascular depression.
- Vasopressors must be prepared, hypotension after RSI is common due to physiology and pre-existing medications.
Obese Patients
- Increased tissue mass challenges every technique: mask ventilation, LMA insertion, intubation, and surgical airway.
- Head-up positioning is beneficial; insert OPA/NPA early.
- Hypoxia occurs more rapidly due to higher rates of pre-existing pulmonary disease, lower respiratory compliance, and reduced FRC.
- Apply higher PEEP post-intubation; medication dose modifications may be required.
Airway Burns
Urgent intubation is generally indicated in the presence of:
- Decreased level of consciousness
- Dyspnoea or stridor
- Decreased SpO₂
- Suprasternal, substernal, or subcostal retraction
- Full-thickness facial burns
- Oedema of oral structures or tongue
If signs are absent, continue frequent reassessment, progressive oedema can cause obstruction. Airway management becomes significantly more difficult once obstruction develops. Early intubation may preempt obstruction; consult burns centre via telehealth when time allows.
Direct Airway Trauma
- Patients often spontaneously assume a position of breathing comfort, allow this if oxygenation is adequate; do not force supine positioning.
- Minimise instrumentation; invasive manoeuvres performed as gently as possible.
- Surgical airway equipment must be immediately available.
- Awake tracheostomy by a qualified surgeon is the safest option when available, this resource is often not available in the rural/remote context.
- A multidisciplinary approach prevents exacerbating injury.
Transfer and Retrieval Decisions
| Clinical Scenario | Rural Action |
|---|---|
| Failed intubation, oxygenation maintained on LMA | Maintain LMA; minimise further attempts; contact RFDS/retrieval immediately |
| Post-RSI, haemodynamically stable | Secure ETT; establish post-intubation sedation/analgesia; arrange CXR; contact retrieval for ICU-level transport |
| Surgical airway performed | Urgent retrieval; surgical airway to be converted to formal tracheostomy at tertiary centre |
| Airway burns, intubated early | Retrieval to burns centre; consult via telehealth |
| Anticipated difficult airway, specialist available remotely | Defer RSI if safe; use telemedicine guidance; temporise with supraglottic airway; await retrieval team |
Pre-retrieval requirements: The airway must be definitively secured before transport. Intubation in a fixed-wing aircraft is extremely hazardous and should be avoided. Confirm ETT position with CXR before departure. Ensure adequate post-intubation sedation and neuromuscular blockade (if required) are established and ongoing supplies are available for transport duration.
Key Rural Practice Points
| Priority | Action |
|---|---|
| Every airway is potentially difficult | Prepare and communicate a rescue plan before every RSI |
| First attempt is the optimal attempt | Optimise all conditions before the first laryngoscopy |
| Surgical airway kit | Stock, audit, and maintain a pre-packed kit in every rural ED |
| Video laryngoscope | Stock and maintain; standard-geometry blade for less-experienced operators |
| Sugammadex | Stock wherever rocuronium is used |
| Capnography | Mandatory for ETT confirmation, minimum colorimetric detector if waveform unavailable |
| Early retrieval notification | Do not wait until crisis, contact RFDS/retrieval coordination early |
| Telehealth | Use state retrieval services for live specialist guidance on difficult airway decisions |
| Simulation training | CICO scenario and surgical airway drill at minimum annually for rural ED teams |
| Post-intubation care | Sedation, analgesia, ventilation, and haemodynamic support established before transfer |
Sources