Overview
- Airway management failure accounts for 8-15% of potentially preventable trauma deaths.
- In the rural and remote Australian context, the stakes are amplified: specialist backup is often hours away, retrieval may be delayed, and the rural generalist must execute a full spectrum of interventions, from basic manoeuvres to surgical cricothyrotomy, with limited personnel and equipment.
Core principles:
- Oxygenation is always the primary goal.
- Not every patient requires intubation; basic manoeuvres or supraglottic devices may suffice until a more controlled environment is available.
- Every emergency airway must be assumed potentially difficult; every management plan must include a plan for failure.
- A definitive airway = a cuffed device placed in the trachea below the vocal cords (cuffed ETT or surgical airway).
- Intubation (outside cardiac arrest) is performed as modified RSI, the terms RSI and modified RSI are used interchangeably.
Indications for Airway Intervention
| Clinical Scenario | Urgency |
|---|---|
| Inability to oxygenate by any other means | Immediate |
| Airway bleeding, regurgitation, or emesis compromising patency | Immediate |
| Unconsciousness / GCS ≤ 8 | Urgent |
| Respiratory failure or impending arrest | Urgent |
| Burns with signs of impending obstruction (stridor, facial oedema, decreased SpO₂, suprasternal retraction, full-thickness facial burns, decreased consciousness) | Urgent-Immediate |
| Penetrating or blunt neck/airway trauma | Urgent |
| Definitive airway required for safe transfer | Planned |
Timing of RSI, Factors to Consider
| Factors Favouring Immediate RSI | Factors Favouring Deferral |
|---|---|
| Cannot oxygenate via mask or supraglottic airway | Adequate resuscitation not yet achieved |
| Inability to maintain airway patency (bleeding, emesis) | Well-functioning supraglottic device or patient self-maintaining airway |
| Definitive airway needed for safe transfer | Haemodynamic instability not yet treated |
| Anticipated deterioration | Inadequate intubation experience or insufficient staff |
| Rapid availability of airway specialist | |
| Anticipated difficult airway with expert help imminent |
A functioning prehospital supraglottic airway providing adequate oxygenation may be continued, with replacement deferred until optimal personnel and equipment are available.
Assessment
Anatomical Predictors of Difficult Airway
| Risk Factor | Clinical Implication |
|---|---|
| Short thyromental distance (< 6 cm) | Anterior larynx, poor laryngoscopic view |
| Restricted mouth opening / jaw protrusion | Difficult blade insertion |
| Retrognathia | Difficult laryngoscopy |
| Obesity / short neck | Reduced FRC, rapid desaturation |
| Beard | Poor BVM seal during mask ventilation |
| Cervical spine immobilisation (MILS/collar) | Reduced neck mobility |
| Previous neck surgery or radiotherapy | Anatomical distortion |
| Pregnancy | Reduced FRC, aspiration risk, airway oedema |
| Obstructive sleep apnoea | Soft tissue obstruction |
| Airway burns / direct airway trauma | Dynamic obstruction, may deteriorate rapidly |
| Large or abnormal neck anatomy | Difficult surgical airway landmark identification |
- A reassuring assessment does not exclude difficult airway.
- Always prepare for failure.
Physiological Predictors of Peri-intubation Risk
- Hypotension: Sedative agents and positive-pressure ventilation reduce preload and can precipitate cardiovascular collapse, fluid resuscitate before RSI; prepare vasopressors.
- Hypoxia: Reduced reserve in obese, pregnant, paediatric, and patients with pre-existing lung disease, maximise preoxygenation.
- Raised ICP: In TBI, laryngoscopy without adequate sedation raises BP and ICP; apnoea causes hypercapnia and further ICP elevation.
- Hyperkalaemia risk with suxamethonium: Contraindicated > 24 hours after extensive burns, prolonged immobilisation, or spinal cord injury.
Investigations
| Investigation | Rural Availability | Clinical Use |
|---|---|---|
| Pulse oximetry (SpO₂) | Universal | Continuous; guide preoxygenation and post-intubation monitoring |
| Waveform capnography (EtCO₂) | Most rural EDs | Mandatory ETT confirmation (≥ 7 sustained breaths); ongoing ventilation monitoring |
| Colorimetric CO₂ detector | All rural EDs (minimum) | Acceptable backup if waveform capnography unavailable |
| ECG | Universal | Continuous monitoring during RSI |
| NIBP | Universal | 1-minute cycle during peri-intubation period |
| POC blood gas (e.g. iSTAT) | Many rural EDs | Pre/post-intubation ventilation and metabolic status |
| Chest X-ray | Most rural EDs | Post-intubation ETT position, pneumothorax |
| POCUS (linear probe) | Selected rural EDs | Localise cricothyroid membrane in obese/oedematous patients; lung sliding to confirm bilateral ventilation |
| Telemedicine / telehealth | Statewide | Real-time specialist guidance for difficult airway planning |
Capnography is the gold standard for ETT confirmation: clinical signs alone (chest rise, air entry, SpO₂) are insufficient and unreliable.
Management
Airway Intervention Spectrum
Escalate stepwise unless immediate advanced airway is mandated:
- Basic manoeuvres: chin lift, jaw thrust; allow spontaneous positioning if patient is oxygenating (especially trauma/airway injury patients)
- Adjuncts: oropharyngeal airway (OPA), nasopharyngeal airway (NPA, avoid if base-of-skull fracture suspected), wide-bore suction
- Supraglottic airway: LMA / i-gel as bridge, temporising, or rescue device
- Tracheal intubation via modified RSI
- Surgical airway: when above measures fail or are contraindicated
Modified RSI
Pre-RSI Preparation Checklist
Use a structured checklist before every RSI. Key elements:
| Domain | Checklist Items |
|---|---|
| Physiological | IV/IO access ×2; resuscitation sufficient; haemodynamics assessed; vasopressor drawn |
| Preoxygenation | High-flow O₂ initiated; apnoeic oxygenation planned |
| Positioning | Head-up/ramped; MILS if C-spine concern |
| Monitoring | SpO₂, EtCO₂, ECG, NIBP on 1-minute cycle |
| Equipment | Suction ×2 checked; laryngoscopes ×2 checked; ETT ×2 cuffs checked; bougie; stylet; syringe; BVM with PEEP valve; OPA; NPA; LMA; surgical airway kit; O₂ supply confirmed |
| Drugs | Induction agent drawn; NMBD drawn; vasopressor(s) drawn; post-intubation sedation ready |
| Team | Roles allocated; intubation plan communicated; failed intubation plan stated; surgical airway plan stated; deterioration plan stated |
Preoxygenation and Apnoeic Oxygenation
- High-flow O₂ via non-rebreather mask (15 L/min) for ≥ 3 minutes; or 8 vital capacity breaths where time is critical.
- In the obtunded patient, assisted BVM ventilation may be required.
- Apnoeic oxygenation: nasal cannulae at 15 L/min maintained throughout laryngoscopy, significantly extends safe apnoea time, particularly important in obese patients, children, and pregnant patients who desaturate rapidly.
RSI Medications
| Drug | Class | Dose | Key Considerations |
|---|---|---|---|
| Ketamine | Dissociative anaesthetic | 0.5-2 mg/kg IV (RSI); 0.5 mg/kg sedation | Drug of choice in haemodynamically unstable patients; bronchodilator; may raise BP/ICP, use with caution in isolated TBI, though current evidence does not absolutely contraindicate it |
| Etomidate | Hypnotic | 0.2-0.3 mg/kg IV | Haemodynamically stable; even a single dose causes transient adrenal suppression, but a single dose is often judged clinically acceptable; avoid infusion |
| Propofol | Hypnotic | Experienced clinician only | Avoid or drastically reduce (up to 90% dose reduction) in shocked patients, profound hypotension risk |
| Midazolam | Benzodiazepine | Reduce 20-40% in elderly/shocked | Hypotension risk; slower onset |
| Fentanyl | Opioid | 0.5-1 mcg/kg | Adjunct sedation/analgesia |
| Suxamethonium | Depolarising NMBD | 1 mg/kg IV | Onset 45-60 sec; offset 3-5 min; contraindicated > 24 h post-extensive burns, prolonged immobilisation, spinal cord injury (fatal hyperkalaemia risk); causes fasciculations |
| Rocuronium | Non-depolarising NMBD | 1.2 mg/kg IV for RSI conditions | Equivalent intubating conditions to suxamethonium at ≥ 1.2 mg/kg; reversible with sugammadex |
$$\text{Rocuronium RSI dose} = 1.2 \; \text{mg/kg}$$
Vasopressors (prepared before induction, not a substitute for volume):
| Agent | Dose |
|---|---|
| Metaraminol | 0.5-1 mg IV boluses (or 10 mcg/kg) |
| Phenylephrine | 50 mcg IV boluses (or 1 mcg/kg) |
| Ephedrine | 6 mg IV boluses (or 0.5 mg/kg) |
| Adrenaline | 10-50 mcg IV boluses; 0.05-2 mcg/kg/min infusion |
| Noradrenaline | 0.1-1 mcg/kg/min infusion (dilute, reliable access) |
- All sedative agents can cause or worsen haemodynamic derangement, doses are reduced compared to elective intubation.
- Fluid resuscitation precedes RSI in haemodynamically unstable patients; vasopressors treat vasodilation from sedatives, not shock itself.
Sugammadex
- If rocuronium is used and surgical airway is not feasible, sugammadex 16 mg/kg IV can reverse profound neuromuscular blockade. However, this is not a routine rescue strategy, waking a trauma patient is rarely a viable option.
- Stock sugammadex in rural EDs where rocuronium is used.
Laryngoscopy
- Approximately 60 seconds after NMBD administration, attempt laryngoscopy.
- Video laryngoscopy (VL) is preferred for trauma intubations, superior first-pass success rates. Standard-geometry VL blades (similar to Macintosh) are appropriate for less experienced operators. Extended-angle blades require additional training.
- Direct laryngoscopy (DL) with Macintosh blade: standard fallback for all rural generalists.
- Bougie (gum-elastic bougie / Eschmann introducer): use early when view is suboptimal; angled tip facilitates anterior passage; railroad ETT over bougie.
- BURP manoeuvre: backward, upward, rightward pressure on larynx by assistant improves laryngoscopic view; also termed external laryngeal manipulation.
- C-spine: MILS by dedicated assistant; remove anterior portion of cervical collar while maintaining MILS.
- If first attempt fails: change something (position, equipment, operator, removal of obstructing material), identical repeated attempts are unlikely to succeed.
Attempt Limits and Escalation
- Maximum 3 laryngoscopy attempts per operator; one further attempt by a more experienced operator is permitted.
- BVM or LMA ventilation is performed between every attempt, do not allow progressive desaturation.
- Every attempt risks progressive oedema and airway injury, fewer attempts are often better.
Confirmation of ETT Placement
- Mandatory primary confirmation: sustained EtCO₂ waveform present for ≥ 7 breaths.
- Secondary: bilateral air entry, symmetric chest rise, SpO₂ trend improvement.
- Visualisation of tube passing through cords is unreliable alone.
- Oesophageal intubation = absent sustained EtCO₂ → remove tube immediately → ventilate via BVM/LMA → do not reattempt until SpO₂ improved.
- Document ETT depth at teeth/gums; secure tube; reassess after every patient movement.
Difficult Airway Algorithm
PREOXYGENATION + APNOEIC OXYGENATION
↓
TRACHEAL INTUBATION ATTEMPTS (max 3; change technique/operator each attempt)
↓ FAIL → Declare "Failed Intubation"
RESCUE AIRWAY: LMA or BVM (max 3 attempts at each; switch if unsuccessful)
↓ FAIL → Declare "Cannot Intubate, Cannot Oxygenate (CICO)"
SURGICAL AIRWAY: Scalpel-Bougie-Tube
Surgical Airway, Emergency Cricothyrotomy
- Indication: CICO situation, failure of tracheal intubation AND supraglottic/BVM rescue.
- Once initiated, persist and secure the airway regardless of challenges encountered.
Preferred technique: Scalpel-Bougie-Tube
| Step | Action |
|---|---|
| 1. Identify | Locate cricothyroid membrane (CTM): midline, between thyroid and cricoid cartilages. Use POCUS (linear probe) if landmarks are impalpable (obesity, oedema, trauma). |
| 2. Stabilise | Non-dominant hand: laryngeal handshake to stabilise larynx. |
| 3. Incise | Horizontal stab incision through skin and CTM with No. 10 or 20 scalpel blade (~1.5-2 cm). |
| 4. Open | Extend and hold incision open with tracheal hook or index finger. |
| 5. Insert bougie | Pass bougie caudally into trachea. |
| 6. Railroad | Pass cuffed 6.0 mm ETT (or purpose-made cricothyrotomy tube) over bougie into trachea. |
| 7. Confirm | Inflate cuff, ventilate, confirm with sustained EtCO₂. |
| 8. Secure | Secure device immediately; document depth. |
$$\text{Once committed to surgical airway, persist. Do not abandon the procedure.}$$
- Rural requirement: Every rural ED must have a pre-packed surgical airway kit (scalpel, tracheal hook, bougie, 6.0 mm cuffed ETT, syringe, tape/securing device).
- Rehearse this procedure in simulation at least annually.
Post-Intubation Management
Use a structured post-intubation checklist:
| Domain | Actions |
|---|---|
| Airway | Confirm sustained EtCO₂; bilateral air entry; document depth at teeth; secure tube; check cuff pressure; reassess after every patient movement |
| Breathing | Safe ventilation initiated; ventilator alarms set; CXR arranged; ABG checked; DOPE mnemonic if deterioration occurs |
| Circulation | Resuscitation continued; vasopressors and fluids available; haemodynamics reassessed |
| Disability | Sedation and analgesia established; head-up position if able; TBI targets maintained; C-spine collar reapplied if applicable |
| Environment | Backup BVM available; O₂ supply adequate; gastric tube inserted |
DOPE mnemonic: causes of post-intubation deterioration:
- D: Displacement (ETT right mainstem or dislodgement)
- O: Obstruction (mucous plug, kink)
- P: Pneumothorax (tension, from positive-pressure ventilation)
- E: Equipment failure (disconnect from ventilator → manual ventilation)
Special Populations
Traumatic Brain Injury (TBI)
- Prevent secondary injury: avoid hypotension, hypoxia, and hypercapnia.
- Laryngoscopy without adequate sedation raises BP and ICP, ensure adequate induction agent dose.
- Apnoea causes hypercapnia and raises ICP, minimise apnoea time.
- Post-intubation: target normocapnia (EtCO₂ 35-40 mmHg); MAP > 80 mmHg; SpO₂ ≥ 95%.
- Ketamine: historical concerns about ICP elevation are not supported by current evidence; remains a reasonable choice especially when haemodynamic instability coexists.
Paediatric Patients
- All airway structures proportionally smaller, use age-appropriate equipment.
- Larger occiput: place shoulder roll (not pillow) to achieve neutral alignment.
- Miller (straight) blade preferred in infants.
- Cuffed ETTs are appropriate for emergency trauma intubations in all age groups, including small children.
- Rapid desaturation due to low FRC, preoxygenation and apnoeic oxygenation are critical.
$$\text{Cuffed ETT internal diameter (mm)} = \frac{\text{age (years)}}{4} + 3.5$$
$$\text{ETT insertion depth at lips (cm)} = \frac{\text{age (years)}}{2} + 12$$
Obstetric Patients
- Reduced FRC (elevated diaphragm), increased aspiration risk (reflux, reduced lower oesophageal sphincter tone), airway oedema.
- Physiological challenges similar to obese patients.
- Left lateral tilt after 20 weeks to relieve aortocaval compression.
- Early RFDS/retrieval involvement.
Elderly Patients
- Reduced protective airway reflexes, high aspiration risk; act decisively.
- Arthritis restricts mouth opening and neck mobility, may worsen with cervical collar.
- Dentures: remove for intubation; leave in place during BVM ventilation to maintain mask seal; if removed, pack gauze between gums and cheek.
- Absence of teeth simplifies intubation but complicates BVM ventilation.
- Reduce RSI sedative doses by 20-40% (barbiturates, benzodiazepines, other sedatives) to reduce cardiovascular depression.
- Vasopressors must be prepared, hypotension after RSI is common due to physiology and pre-existing medications.
Obese Patients
- Increased tissue mass challenges every technique: mask ventilation, LMA insertion, intubation, and surgical airway.
- Head-up positioning is beneficial; insert OPA/NPA early.
- Hypoxia occurs more rapidly due to higher rates of pre-existing pulmonary disease, lower respiratory compliance, and reduced FRC.
- Apply higher PEEP post-intubation; medication dose modifications may be required.
Airway Burns
Urgent intubation is generally indicated in the presence of:
- Decreased level of consciousness
- Dyspnoea or stridor
- Decreased SpO₂
- Suprasternal, substernal, or subcostal retraction
- Full-thickness facial burns
- Oedema of oral structures or tongue
- If signs are absent, continue frequent reassessment, progressive oedema can cause obstruction.
- Airway management becomes significantly more difficult once obstruction develops.
- Early intubation may preempt obstruction; consult burns centre via telehealth when time allows.
Direct Airway Trauma
- Patients often spontaneously assume a position of breathing comfort, allow this if oxygenation is adequate; do not force supine positioning.
- Minimise instrumentation; invasive manoeuvres performed as gently as possible.
- Surgical airway equipment must be immediately available.
- Awake tracheostomy by a qualified surgeon is the safest option when available, this resource is often not available in the rural/remote context.
- A multidisciplinary approach prevents exacerbating injury.
Transfer and Retrieval Decisions
| Clinical Scenario | Rural Action |
|---|---|
| Failed intubation, oxygenation maintained on LMA | Maintain LMA; minimise further attempts; contact RFDS/retrieval immediately |
| Post-RSI, haemodynamically stable | Secure ETT; establish post-intubation sedation/analgesia; arrange CXR; contact retrieval for ICU-level transport |
| Surgical airway performed | Urgent retrieval; surgical airway to be converted to formal tracheostomy at tertiary centre |
| Airway burns, intubated early | Retrieval to burns centre; consult via telehealth |
| Anticipated difficult airway, specialist available remotely | Defer RSI if safe; use telemedicine guidance; temporise with supraglottic airway; await retrieval team |
- Pre-retrieval requirements: The airway must be definitively secured before transport.
- Intubation in a fixed-wing aircraft is extremely hazardous and should be avoided.
- Confirm ETT position with CXR before departure.
- Ensure adequate post-intubation sedation and neuromuscular blockade (if required) are established and ongoing supplies are available for transport duration.
Key Rural Practice Points
| Priority | Action |
|---|---|
| Every airway is potentially difficult | Prepare and communicate a rescue plan before every RSI |
| First attempt is the optimal attempt | Optimise all conditions before the first laryngoscopy |
| Surgical airway kit | Stock, audit, and maintain a pre-packed kit in every rural ED |
| Video laryngoscope | Stock and maintain; standard-geometry blade for less-experienced operators |
| Sugammadex | Stock wherever rocuronium is used |
| Capnography | Mandatory for ETT confirmation, minimum colorimetric detector if waveform unavailable |
| Early retrieval notification | Do not wait until crisis, contact RFDS/retrieval coordination early |
| Telehealth | Use state retrieval services for live specialist guidance on difficult airway decisions |
| Simulation training | CICO scenario and surgical airway drill at minimum annually for rural ED teams |
| Post-intubation care | Sedation, analgesia, ventilation, and haemodynamic support established before transfer |